Following promulgation of the Nuremberg code in 1947, the ethics of research on human subjects has been a challenging and often contentious topic of debate. Escalation in the use of research participants in low-income countries over recent decades , has intensified the debate on the ethics of international research and led to increasing attention both to exploitation of vulnerable subjects and to considerations of how the 10:90 gap in health and medical research could be narrowed. In 2000, prompted by the (...) discussions over several years that led to the US NIH launching a capacity building programme on research ethics for members of research ethics committees in developing countries, we advanced a ‘new look’ for the ethics of international research.1 Since then progress has been made on several fronts.First, our ideas—considered somewhat radical and impractical at the time—have been provocatively addressed by scholars who have either contested them or advanced similar conceptions of what obligations international researchers have to research participants and communities in low income countries before, during and after clinical trials. Second, those researchers who have been sympathetic to our ideas have either endeavoured to put these into practice or have investigated the feasibility of doing so. Third, the intractability of the 10/90 gap and the escalation of interest in global health have sensitised many to the need to amplify the uptake of these ideas in practice.Here, we briefly review the conceptual and practical developments in international research ethics. While much conceptual progress has been made (and the concepts are now appearing …. (shrink)

Tara Smith's book on Rand's ethics is reviewed by Stephen Hicks for *Philosophy in Review.*.

This set reprints volumes that were orginally published by Routledge and Kegan Paul Ltd. in 1953. Landmark volumes at the time of their original publication, these titles do not merely expound the theoretical constructions of Russian philosophers, but also relate these constructions to the general conditions of Russian life. Volume One examines the historical conditions of the development of philosophy in Russia and explores the general features of Russian philosophy. It also surveys the principal works on the history of Russian (...) philosophy. Volume Two includes biographies and examination of the themes of the following philosophers; Vladimir Solovyov, V.D. Kudryavtsev, N.F. Fyodorov and Later Hegelians such as Chicherin, Debolski and Bakunin. This volume also provides analysis of various schools of thought in Russian philosophy in the twentieth century, for example; Neo-Leibzianism, Modern Positivism and New-Marxism to name but a few. (shrink)

First published in 2000. Routledge is an imprint of Taylor & Francis, an informa company.

This paper seeks to explore the implementation of corporate ethical culture and policies as an adjunct to formal forms of corporate governance. The insurance industry utilises a variety of external governance structures, but is almost unique in that stock companies (which are exposed to an external market for corporate control) and mutual companies (which are owned by a subset of their customers) are in active competition. A questionnaire survey of senior executives in U.K. insurance companies was undertaken to explore the (...) implementation of ethical policies and codes, to investigate ethical attitudes, and to analyze the extent to which these policies and attitudes varied among companies. The results suggest that ethical policies have a higher profile and ethical attitudes and behaviour are more positive in mutual as opposed to stock insurance companies. These findings support the contention that a strong corporate ethical culture may be utilised to enhance formal corporate governance instruments. (shrink)

SummaryAn accurate framework for interpreting Kant's theory of knowledge must clearly distinguish between the six terms he uses to describe the various stages in the epistemological development of the‘object’of knowledge. Kant portrays the object transcendentally in the first Critique as passing from an unknowable‘thing in itself through the intermediate stage of being a‘transcendental object’, and finally attaining the ideal status of an‘appearance’. When the object is considered empirically, it passes through three corresponding stages: the‘phenomenon’is the real object as known in (...) experience, the‘negative noumenon’limits our knowledge to its intuitive manifestation, and the‘positive noumenon’is that aspect of the known object which remains ultimately transcendent. (shrink)

A number of enigmatic manuscripts of Plato have been identified during the last few decades. Thus Mercati , 35) showed that Angelicus c.1.9 , which L. A. Post was unable to trace, is identical to Rossianus 17; N. G. Wilson , 393 n.2) proved that the long-lost Hassistenianus is no other than the Lobcovicianus in Prague University Library Here is the solution of a thirdpuzzle.

The Clitophon, a dialogue generally ascribed to Plato, is significant for focusing on Socrates' role as an exhorter of other people to engage in philosophy. It was almost certainly intended to bear closely on Plato's Republic and is a fascinating specimen of the philosophical protreptic, an important genre very fashionable at the time. This 1999 volume is a critical edition of this dialogue, in which Professor Slings provides a text based on an examination of all relevant manuscripts and accompanies it (...) with a translation. His extensive introduction studies philosophical exhortation in the classical era, and tries to account for Plato's dialogues in general as a special type of exhortation. The Clitophon is seen as a defence of the Platonic dialogue. The commentary elucidates the Greek and discusses many passages where the meaning is not entirely clear. (shrink)

We present a model of steady state solute and water reabsorption along the rat proximal tubule. Major co-and counter-transport systems in the apical and basolateral cell membranes are described using kinetic descriptions based on data from the flows and solute concentrations along the length of the proximal tubule as a function of filtration rate and peritubular solute concentrations. We show that for many aspects of proximal tubule transport physiology this kinetics-based model is an adequate representation of the mammalian proximal tubule.

Quest after values and their realization constitute innate necessity for human being. This presupposes knowledge of Reality and knowledge of the value-schema. In this context, a distinction can be drawn between descriptive awareness of Reality and prescriptive awareness of Values. For the latter, the pῡrva mimāmsā system postulates ‘codanā’ as a means of knowledge. In Indian Culture, two types of values are enunciated, viz. preyas and śreyas. The Taittirῑya upaniṣad puts forth a five-dimensional theory of human constitution and accordingly advocates (...) a fivefold value-schema. In general, theory of puruṣartha has been accepted by all the cultural traditions of India with variant details. It would be interesting and enlightening to discuss different aspects and issues concerning this theory. Knowledgeable scholars may delineate on related issues as well. (shrink)

The problem of becoming a social doctrine of Ukrainian Christianity, in particular Ukrainian Catholicism, has become especially relevant today in theological, philosophical and religious sciences, since objective study contributes to the production of not only a true picture of the Church-theological identity of the Ukrainian Orthodox ), which entrenched the historically and theologically not justified name - Ukrainian Greek Catholic Church, but also the place and role of Christianity in modern times. to this Ukrainian public life in general. Ukrainian Catholicism, (...) represented by the Ukrainian Catholic Church, the heir to the Kyiv Church, has accumulated significant experience of collaborating with the public in various spheres of its activity, including in the social sphere, for more than a thousand years. (shrink)

The discovery of selective associability of cues in classical conditioning has often been treated as an embarrassment to Pavlov, because he has been represented as a proponent of the "equivalence of associability of cues." According to that doctrine, except for the influence of differences in stimulus intensity, all environmental stimuli are equally susceptible to becoming conditioned stimuli if they are arranged in a suitable time-relation to any effective unconditioned stimulus . The current paper asks whether Pavlov explicitly made such a (...) claim and, if not, whether he could have endorsed equivalence of associability. Scientific controversy, the role that "the classics" play in scientific specialties, and the emblematic standing of the founding figures of a discipline or specialty constitute a framework for discussion of Pavlov's stand on the equivalence of associability. (shrink)

As Leibniz had hoped, the publication of his ‘Système nouveau de la nature et de la communication des substances...’ in 1695 provoked discussion of his metaphysics. Amongst the reactions was that of the French Benedictine, François Lamy, in his De la Connaissance de soi-même. It is not unusual to find the different editions of this work being confused, to the detriment of a proper understanding of the relation between Lamy’s texts and Leibniz’s. No doubt the rarity of copies of De (...) la Connaissance is at least partly responsible for this confusion, and it is because of that rarity that Lamy’s discussion of Leibniz is made available and reprinted here. (shrink)